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1) Result : To produce materials for much less time compared to Batch type process and ensure safety
Comparison in refining of nucleic acid between Batch type and Taylor reactor.
class. Batch type reactor Taylor reactor
Process time(h) 8~9 0.5
Productivity per working volume(kg/h . m3) 10.7 1048
Energy consumption(TOE/ton) 25,200 15,200
Purity(%) 97 99.9
Crystallinity(%) 90 98
Reactor capacity (m3), base- 1.8ton/day 21.0 0.27
Process type Batch process continuous process
by the research of GMP material

GMP (5`-guanosine monophosphate)
  • The ingredient of nucleotide seasoning
class. GMP
Mol.formula C10H12O8N5PNa2­7H2O
Mol.wt 533.26
Spec. Appearance White crystalline powder
Purity 97~102%
pH 7.0~8.5
Arsenic Less than 1.5ppm
Heavy Metals Less than 10ppm
Flavor Pine mushroom
Loss on drying less than 25%



2) Research data
CONVENTIONAL PROCESS




3) Research data
Experiment method




Comparison , particle size vs reaction time


Mfg. Condition
Concentration(g/L) 200 S-AS ratio 1
Agitation speed(rpm) 400 Temp.(℃) 75
d / ri 0.22 Variable Reaction time



Characteristics on the changes of reaction time


Mfg. Condition
Concentration(g/L) 200 S-AS ratio 1
Agitation speed(rpm) 400 Temp.(℃) 75
d / ri 0.22 Variable Reaction time



Comparison , Ave. particle size vs d/ri


Mfg. Condition
Concentration(g/L) 200 Reaction time(min) 20
Agitation speed(rpm) 400 Temp.(℃) 75
S-AS ratio 1 Variable d/ri



Comparison, Ave. particle size vs conc. GMP


Experiment condition
Agitation speed(rpm) 400 Reaction time(min) 20
d / ri 0.22 Temp.(℃) 75
S-AS ratio 1 Variable GMP solution conc.



Comparison, Ave.particle size vs Anti-solvent fraction


Mfg. Condition
Concentration(g/l) 200 Reaction time(min) 20
Agitation speed (rpm) 400 Temp.(℃) 75
d / ri 0.22 Variable S-AS ratio



Comparison, Ave. particle size vs Rotation speed


Mfg. Condition
Concentration(g/l) 200 Reaction time(min) 20
d / ri 0.22 Temp.(℃) 75
S-AS ratio 1 Variable rotation speed(rpm)



Comparison, characteristics on scale-up


Mfg. Condition
Conc.(g/L) 200 Reaction time(min) 5
Agitation speed(rpm) 400 Temp.(℃) 75
d / ri 0.419 Step feeding ratio of AS 7:1:2
S-AS ratio 1 Variable reaction volume



Comparison, characteristics on scale-up




Experiment result, neutralizing crystallization of tryptophan

Particle size Recovery ratio Purity
200mm ↑ 75%↑ 98%↑


Big crystals create by just the control of pH Possible to produce a big tryptophan crystal
By optimizing the mfg. Process in case tryptophan in the condition of Broth is supplied.




Experiment result, cooling crystallization of methionine

Particle size Recovery ratio Purity
150 ㎛↑ 60%↑ 98%↑


Temp: 60 ℃ -> 20 ℃ (cooling)
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